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Homeotic selector genes code
for DNA binding proteins (transcription factor)
-transcriptiefactor:
•
homeodomain
(protein)
•
homeobox
(DNA)
•
interaction with DNA and with
other regulatory proteins
•
helix-turn-helix DNA binding
motif
•
60 amino acids
domain
•
HOX genes are a subgroup of
homeobox genes
*Order of sequence
matches the spatial order of expression
-HOX complex:
chromosome region with hox genes